When legal issues complicate matters that stall a life-saving bone marrow transplant, Sharon Goodwin must decide whether to disobey direct orders or stand by and put a patient's life in jeopardy. April tends to a caring, homeless man who Dr. Charles evaluates, only to come to an unusual diagnosis that explains his recent behavior. Dr. Natalie Manning's parents come to town to see their new grandchild, much to the dismay of her mother-in-law, Helen. Dr. Connor Rhodes treats a couple who are injured on their first date by a hit-and-run driver, who Dr. Halstead discovers has his own reasons for causing the accident.