In the premiere episode, "Pilot," Dr. Henry Morgan's exciting, adventurous and intriguing long life has blessed him with amazing insight and observational skills. So, when Henry and Detective Jo Martinez investigate a fatal subway collision, Jo not only is impressed, but her curiosity is peeked about who he is. Meanwhile, Henry soon discovers someone else knows his secret. He may not be the only "immortal" out there. But who is that person and what does he want? The one person who can inject hope into Henry's life is Abe, his best and only friend. Fate has brought the two men together and they share an unconventional bond. It's just part of the captivating mystery surrounding Henry's strange circumstances and his long search to uncover the cause of his condition and escape.