Unlike the other four episodes, "Up All Night" does not take place in the TARDIS control room, and neither the Doctor nor any of the Williams/Pond family appears.
This episode is a prequel to "Closing Time" by Gareth Roberts, and shows the night spent by Craig Owens (James Corden) before the Doctor pays him a visit. Craig faces his fears of being a father and caring for young Alfie, while Sophie Benson (Daisy Haggard) prepares for her trip and the lights flicker ominously.