The doctors of Seattle Grace are called upon to man up when a stampede at a comic book convention causes an influx of colorful characters in the ER - blurring the lines of fantasy and reality; Mark shows his softer side with baby Sofia when Arizona and Callie go out of town, but at work he continues to give Jackson a hard time; Ben returns to the ER, only to find that Nurse Eli has moved in on Bailey; and the male doctors bond over their frustrations with women.