During a meningitis outbreak that overwhelms the resources and staff of Princeton-Plainsboro Teaching Hospital, House singles out a 12-year-old patient whose symptoms are similar to but not quite right for the disease. House, Foreman, and Chase must devise ingenious ways and locations to treat the girl's delicate condition in the middle of the chaos and make an unexpected discovery. Meanwhile, House asks Cameron to come back to her job, but she has one requirement that he might not be able to meet.