As House and his team diagnose Vince, a man with a giant, swollen tongue, a disgruntled former patient Jack Moriarty walks into House's office and shoots him. House continues treating his patient from his ICU hospital bed with Jack, who hospital security shot and hand-cuffed to his bed, as his roommate. When the after-effects of the shooting begin to impact House, he starts to question his ability to diagnose correctly. As his patient's body deteriorates, House struggles through his self-doubt and must trust his team to find a way to solve the case.